Stromal Antiapoptotic Paracrine Loop in Perineural Invasion of Prostatic Carcinoma
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چکیده
منابع مشابه
Sonic hedgehog paracrine signaling activates stromal cells to promote perineural invasion in pancreatic cancer.
PURPOSE Pancreatic cancer is characterized by stromal desmoplasia and perineural invasion (PNI). We sought to explore the contribution of pancreatic stellate cells (PSC) activated by paracrine Sonic Hedgehog (SHH) in pancreatic cancer PNI and progression. EXPERIMENTAL DESIGN In this study, the expression dynamics of SHH were examined via immunohistochemistry, real-time PCR, and Western blot a...
متن کاملBiology of Human Tumors Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer
Purpose: Pancreatic cancer is characterized by stromal desmoplasia and perineural invasion (PNI). We sought to explore the contribution of pancreatic stellate cells (PSC) activated by paracrine Sonic Hedgehog (SHH) in pancreatic cancer PNI and progression. Experimental Design: In this study, the expression dynamics of SHH were examined via immunohistochemistry, real-time PCR, and Western blot a...
متن کاملConsensus transcriptome signature of perineural invasion in pancreatic carcinoma.
Perineural invasion, the growth of tumor cells along nerves, is a key feature of pancreatic cancer. The cardinal symptom of pancreatic cancer, abdominal pain often radiating to the back, as well as the high frequency of local tumor recurrence following resection are both attributed to the unique ability of pancreatic tumor cells to invade the neuronal system. The molecular mechanisms underlying...
متن کاملAgr2 mediates paracrine effects on stromal fibroblasts that promote invasion by gastric signet-ring carcinoma cells.
Agr2 is a disulfide isomerase residing in the endoplasmic reticulum (ER), which physiologically regulates protein folding and mediates resistance to ER stress. Agr2 is overexpressed in adenocarcinomas of various organs, where it participates in neoplastic transformation and metastasis, therefore acts as a pro-oncogenic protein. Besides its normal localization in the ER, Agr2 is also found in th...
متن کامل[Management of basal cell carcinoma with perineural invasion].
The presence of perineural invasion in skin tumors constitutes a major risk factor for local recurrence.1-3 Perineural invasion is not a common finding in basal cell carcinomas, with an estimated incidence that, depending on the series, varies between 0.17%2 and 3.8%.4 The frequency is higher in more aggressive histological subtypes and in recurrent tumors.1,2,4,5 The patient was a 69-year-old ...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2006
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-05-1847